Sequential generalized likelihood ratio tests for vaccine safety evaluation

Sequential generalized likelihood ratio tests for vaccine safety evaluation.

The evaluation of vaccine safety involves pre-clinical animal studies, pre-licensure randomized clinical trials, and post-licensure safety studies. Sequential design and analysis are of particular interest because they allow early termination of the trial or quick detection that the vaccine exceeds a prescribed bound on the adverse event rate. After a review of the recent developments in this a...

Generalized likelihood ratio tests

Generalized Likelihood Ratio Tests for Additive Models

Composite Hypotheses and Generalized Likelihood Ratio Tests

In many real world problems, it is difficult to precisely specify probability distributions. Our models for data may involve unknown parameters or other characteristics. Here are a few motivating examples. Example: Unknown amplitudes/delays in wireless communications. We don't always know how many relays a signal will go through, how strong the signal will be at each receiver, the distance betw...

Likelihood Ratio Tests for